| http://purl.uniprot.org/citations/23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23515283 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic steatosis is emerging as the most important cause of chronic liver disease and is associated with the increasing incidence of obesity with insulin resistance. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene expression in the liver. Hyperinsulinemia induces SREBP-1c transcription through liver X receptor (LXR), specificity protein 1, and SREBP-1c itself. Clusterin, an 80-kDa disulfide-linked heterodimeric protein, has been functionally implicated in several physiological processes including lipid transport; however, little is known about its effect on hepatic lipogenesis. The present study examined whether clusterin regulates SREBP-1c expression and lipid accumulation in the liver. Adenovirus-mediated overexpression of clusterin inhibited insulin- or LXR agonist-stimulated SREBP-1c expression in cultured liver cells. In reporter assays, clusterin inhibited SREBP-1c promoter activity. Moreover, adenovirus-mediated overexpression of clusterin in the livers of mice fed a high-fat diet inhibited hepatic steatosis through the inhibition of SREBP-1c expression. Reporter and gel shift assays showed that clusterin inhibits SREBP-1c expression via the repression of LXR and specificity protein 1 activity. This study shows that clusterin inhibits hepatic lipid accumulation through the inhibition of SREBP-1c expression and suggests that clusterin is a negative regulator of SREBP-1c expression and hepatic lipogenesis."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2012-2009"xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Lee I.K."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Kim M.K."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Park K.G."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Seo H.Y."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Jung Y.A."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Jang B.K."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/author | "Yoo E.K."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/pages | "1722-1730"xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/title | "Clusterin decreases hepatic SREBP-1c expression and lipid accumulation."xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/23515283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23515283 |
| http://purl.uniprot.org/citations/23515283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23515283 |
| http://purl.uniprot.org/uniprot/#_E9Q8Y5-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_E9Q9B8-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_E9Q2G2-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_E9PXG5-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_D6RFP9-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_E9PUU2-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_Q06890-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |
| http://purl.uniprot.org/uniprot/#_Q3V245-mappedCitation-23515283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23515283 |