| http://purl.uniprot.org/citations/23516296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23516296 | http://www.w3.org/2000/01/rdf-schema#comment | "Excitatory acetylcholine motor neurons drive Caenorhabditis elegans locomotion. Coordinating the activation states of the backward-driving A and forward-driving B class motor neurons is critical for generating sinusoidal and directional locomotion. Here, we show by in vivo calcium imaging that expression of a hyperactive, somatodendritic ionotropic acetylcholine receptor ACR-2(gf) in A and B class motor neurons induces aberrant synchronous activity in both ventral- and dorsal-innervating B and A class motor neurons. Expression of ACR-2(gf) in either ventral- or dorsal-innervating B neurons is sufficient for triggering the aberrant synchrony that results in arrhythmic convulsions. Silencing of AVB, the premotor interneurons that innervate B motor neurons suppresses ACR-2(gf)-dependent convulsion; activating AVB by channelrhodopsin induces the onset of convulsion. These results support that the activity state of B motor neurons plays an instructive role for the coordination of motor circuit."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4017-12.2013"xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Kawano T."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Mac P."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Qi Y.B."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/author | "Po M.D."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/pages | "5319-5325"xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/title | "Hyperactivation of B-type motor neurons results in aberrant synchrony of the Caenorhabditis elegans motor circuit."xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23516296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23516296 |
| http://purl.uniprot.org/citations/23516296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23516296 |
| http://purl.uniprot.org/uniprot/#_P48182-mappedCitation-23516296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23516296 |
| http://purl.uniprot.org/uniprot/P48182 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23516296 |