| http://purl.uniprot.org/citations/23516302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23516302 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease is thought to be caused by β-amyloid peptide (Aβ)-dependent synaptic dysfunction. However, the signaling pathways connecting Aβ and synaptic dysfunction remain elusive. Here we report that Aβ transiently increases the expression level of centaurin-α1 (CentA1) in neurons, which induces a Ras-dependent association of Elk-1 with mitochondria, leading to mitochondrial and synaptic dysfunction in organotypic hippocampal slices of rats. Downregulation of the CentA1-Ras-Elk-1 pathway restored normal mitochondrial activity, spine structural plasticity, spine density, and the amplitude and frequency of miniature EPSCs in Aβ-treated neurons, whereas upregulation of the pathway was sufficient to decrease spine density. Elevations of CentA1 and association of Elk-1 with mitochondria were also observed in transgenic mice overexpressing a human mutant form of amyloid precursor protein. Therefore, the CentA1-Ras-Elk-1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to Aβ in hippocampal neurons, providing new pharmacological targets for Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2641-12.2013"xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/author | "Yasuda R."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/author | "Oliveira A.F."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/author | "Sumner E.J."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/author | "Szatmari E.M."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/pages | "5367-5374"xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/title | "Centaurin-alpha1-Ras-Elk-1 signaling at mitochondria mediates beta-amyloid-induced synaptic dysfunction."xsd:string |
| http://purl.uniprot.org/citations/23516302 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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