| http://purl.uniprot.org/citations/23520314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23520314 | http://www.w3.org/2000/01/rdf-schema#comment | "Peribronchial angiogenesis may occur in cystic fibrosis and vascular endothelial growth factor (VEGF)-A regulates angiogenesis in airways. Peribronchial vascularity and VEGF-A expression were examined using immunocytochemistry and morphometric analysis in lung sections obtained in 10 cystic fibrosis patients at transplantation versus 10 control nonsmokers, and in two strains of Cftr-deficient mice versus wild-type littermates. Airway epithelial NCI-H292 cells and primary cultures of noncystic fibrosis human airway epithelial cells were treated with cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors (CFTR-inh(172) or PPQ-102) or transfected with a CFTR small interfering (si)RNA with or without a selective epidermal growth factor receptor tyrosine kinase inhibitor. Concentrations of VEGF-A and phosphorylated epidermal growth factor receptor were measured by ELISA. Peribronchial vascularity was increased in cystic fibrosis patients, but not in Cftr-deficient mice. VEGF-A immunostaining was localised to airway epithelium and was increased in cystic fibrosis patients and in Cftr-deficient mice. In cultured airway epithelial cells, treatment with CFTR inhibitors or transfection with CFTR siRNA induced a twofold increase in VEGF-A production. CFTR inhibitors triggered epidermal growth factor receptor phosphorylation that was required for VEGF-A synthesis. Cystic fibrosis airways at transplantation showed increased peribronchial vascularity and epithelial VEGF-A expression. CFTR dysfunction triggered epithelial synthesis of VEGF-A, which may contribute to vascular remodelling."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.org/dc/terms/identifier | "doi:10.1183/09031936.00164212"xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Papon J.F."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Touqui L."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Coste A."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Escudier E."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Fajac I."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Burgel P.R."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Dusser D.J."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Pruliere-Escabasse V."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Thevenot G."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/author | "Coolen N."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/name | "Eur Respir J"xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/pages | "1553-1562"xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/title | "CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium."xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/23520314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23520314 |
| http://purl.uniprot.org/citations/23520314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23520314 |
| http://purl.uniprot.org/uniprot/#_A0A089NFM8-mappedCitation-23520314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23520314 |
| http://purl.uniprot.org/uniprot/#_A0A089PPW6-mappedCitation-23520314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23520314 |
| http://purl.uniprot.org/uniprot/#_A0A088T1A1-mappedCitation-23520314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23520314 |