| http://purl.uniprot.org/citations/23521884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23521884 | http://www.w3.org/2000/01/rdf-schema#comment | "The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1-specific CD8+ T cell responses directed against the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263-272) presented by human leukocyte antigen (HLA)-B∗2705. We found that cross-reactive CD8+ T cell clonotypes were mobilized to counter the rapid emergence of HIV-1 variants that can directly affect T cell receptor (TCR) recognition. These newly recruited clonotypes expressed TCRs that engaged wild-type and mutant KK10 antigens with similar affinities and almost identical docking modes, thereby accounting for their antiviral efficacy in HLA-B∗2705+ individuals. A protective CD8+ T cell repertoire therefore encompasses the capacity to control TCR-accessible mutations, ultimately driving the development of more complex viral escape variants that disrupt antigen presentation."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.11.021"xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Hashimoto M."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Almeida J.R."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Wilmann P.G."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Meyer L."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Venturi V."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Takiguchi M."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Ladell K."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "McLaren J.E."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Appay V."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Kuse N."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Douek D.C."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Chikata T."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Agut H."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Venet A."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Iglesias M.C."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "van Bockel D.J."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Arkoub Z.A."xsd:string |
| http://purl.uniprot.org/citations/23521884 | http://purl.uniprot.org/core/author | "Bridgeman J.S."xsd:string |