| http://purl.uniprot.org/citations/23522044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23522044 | http://www.w3.org/2000/01/rdf-schema#comment | "Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in heterologous cells, but their role in neurons is unclear. Using CNIH-2 and CNIH-3 conditional knockout mice, we find a profound reduction of AMPAR synaptic transmission in the hippocampus. This deficit is due to the selective loss of surface GluA1-containing AMPARs (GluA1A2 heteromers), leaving a small residual pool of synaptic GluA2A3 heteromers. The kinetics of AMPARs in neurons lacking CNIH-2/-3 are faster than those in WT neurons due to the fast kinetics of GluA2A3 heteromers. The remarkably selective effect of CNIHs on the GluA1 subunit is probably mediated by TARP γ-8, which prevents a functional association of CNIHs with non-GluA1 subunits. These results point to a sophisticated interplay between CNIHs and γ-8 that dictates subunit-specific AMPAR trafficking and the strength and kinetics of synaptic AMPAR-mediated transmission."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2013.01.017"xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Nicoll R.A."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Roche K.W."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Suh Y.H."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Herring B.E."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Zheng C.Y."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/author | "Blankenship S.M."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/pages | "1083-1096"xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/title | "Cornichon proteins determine the subunit composition of synaptic AMPA receptors."xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/23522044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23522044 |
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