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| http://purl.uniprot.org/citations/23523245 | http://www.w3.org/2000/01/rdf-schema#comment | "Numb acts as a cell-fate determinant during asymmetric and stem cell divisions in both vertebrates and invertebrates [1, 2]. In Drosophila, Numb is unequally segregated in asymmetrically dividing sensory organ precursor cells (SOPs). Numb is inherited by the pIIb cell (Notch OFF) and is absent from the pIIa cell (Notch ON) [3, 4]. Numb is required to establish directional Notch signaling during cytokinesis [3, 5-7]. Using real-time imaging of a functional GFP-tagged Numb, we show that Numb relocalizes during cytokinesis from the basal cortex of pIIb to subapical endosomes. This relocalization appeared to depend on its interaction with the α-adaptin [8, 9]. Live imaging of Sanpodo (Spdo), a membrane protein interacting with Numb and regulating the trafficking of Notch [6, 7, 10-15], revealed that Spdo is internalized during cytokinesis and coaccumulates with Numb in pIIb endosomes. Using a GFP-tagged Notch [6], we found that Notch coaccumulates with Spdo in a Numb-dependent manner in these pIIb endosomes. Numb was, however, dispensable for the internalization of Notch and Spdo. We propose that Numb interacts with internalized Spdo-Notch oligomers at sorting endosomes and inhibits the recycling of Notch, thereby creating an asymmetry in Notch distribution along the pIIa-pIIb interface and regulating binary fate choice."xsd:string |
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| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/author | "Schweisguth F."xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/author | "Mazouni K."xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/author | "Couturier L."xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/pages | "588-593"xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/title | "Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/23523245 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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