| http://purl.uniprot.org/citations/23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23526216 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous epidemiological studies have linked exposure to particulate matter (PM) air pollution with acute respiratory infection and chronic respiratory and cardiovascular diseases. We have previously shown that soluble nickel (Ni), a common component of PM, alters the release of CXC chemokines from cultured human lung fibroblasts (HLF) in response to microbial stimuli via a pathway dependent on disrupted prostaglandin (PG)E2 signaling. The current study sought to identify the molecular events underlying Ni-induced alterations in PGE2 signaling and its effects on IL-8 production. PGE2 synergistically enhances Ni-induced IL-8 release from HLF in a concentration-dependent manner. The effects of PGE2 were mimicked by butaprost and PGE1-alcohol and inhibited with antagonists AH6809 and L-161,982, indicating PGE2 signals via PGE2 receptors 2 and 4. PGE2 and forskolin stimulated cAMP, but it was only in the presence of Ni-induced hypoxia-inducible factor 1, α subunit (HIF1A) that these agents stimulated IL-8 release. The Ni-induced HIF1A DNA binding was enhanced by PGE2 and mediated, in part, by activation of p38 MAPK. Negation of cAMP-response element binding protein 1 or HIF1A using short interfering RNA blocked the synergistic interactions between Ni and PGE2. The results of the current study provide novel information on the ability of atmospheric hypoxia-mimetic metals to disrupt the release of immune-modulating chemokines by HLF in response to PGE2. Moreover, in the presence of HIF1A, cAMP-mediated signaling pathways may be altered to exacerbate inflammatory-like processes in lung tissue, imparting a susceptibility of PM-exposed populations to adverse respiratory health effects."xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2012-0297oc"xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/author | "Fabisiak J.P."xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/author | "Brant K.A."xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/pages | "105-113"xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/title | "Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23526216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23526216 |
| http://purl.uniprot.org/citations/23526216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23526216 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B7Z7P1-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B4E2K5-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B4E2U7-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B4DL76-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B4DS34-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_B7Z5C6-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_I7GY10-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_Q16118-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |
| http://purl.uniprot.org/uniprot/#_Q53X93-mappedCitation-23526216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23526216 |