| http://purl.uniprot.org/citations/23526584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23526584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23526584 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine leukemia P388 in vivo. In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold. Here, we report the crystal structure of SsfS6 in the free form and in complex with TDP, both at 2.4 Å resolution. The structures reveal SsfS6 to adopt a GT-B fold wherein the TDP and docked putative aglycon are consistent with the overall C-glycosylation reaction. As one of only a few existing structures for C-glycosyltransferases, the structures described herein may serve as a guide to better understand and engineer C-glycosylation."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.org/dc/terms/identifier | "doi:10.1002/prot.24289"xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.org/dc/terms/identifier | "doi:10.1002/prot.24289"xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Bingman C.A."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Bingman C.A."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Phillips G.N. Jr."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Thorson J.S."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Thorson J.S."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Phillips G.N."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Yennamalli R.M."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/author | "Yennamalli R.M."xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/name | "Proteins"xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/name | "Proteins"xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/pages | "1277-1282"xsd:string |
| http://purl.uniprot.org/citations/23526584 | http://purl.uniprot.org/core/pages | "1277-1282"xsd:string |