| http://purl.uniprot.org/citations/23528710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23528710 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. More than 30% of patients develop lung metastasis, which is the leading cause of mortality. Recently, the extracellular matrix protein Cyr61 has been recognized as a malignancy promoting protein in OS mouse model with prognostic potential in human OS. In this study, we aimed at the identification of novel Cyr61-interacting proteins. Here we report that Cyr61 associates with Caprin-1, and confocal microscopy showed that stable ectopic expression of Caprin-1 leads to the formation of stress granules containing Caprin-1 and Cyr61, confers resistance to cisplatin-induced apoptosis, and resulted in constitutive phosphorylation of Akt and ERK1/2. Importantly, ectopic expression of Caprin-1 dramatically enhanced primary tumor growth, remarkably increased lung metastatic load in a SCID intratibial OS mouse model, and decreased significantly (p<0.0018) the survival of the mice. Although Caprin-1 expression, evaluated with a tissue microarray including samples from 59 OS patients, failed to be an independent predictor for the patients' outcome in this limited cohort of patients, increased Caprin-1 expression indicated a tendency to shortened overall survival, and more strikingly, Cyr61/Caprin-1 co-expression was associated with worse survival than that observed for patients with tumors expressing either Cyr61 or Caprin-1 alone or none of these proteins. The findings imply that Caprin-1 may have a metastasis promoting role in OS and show that through resistance to apoptosis and via the activation of Akt and ERK1/2 pathways, Caprin-1 is significantly involved in the development of OS metastasis."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2013.03.014"xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Hess D."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Ziegler U."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Born W."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Muff R."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Fuchs B."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Husmann K."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Arlt M.J."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Bertz J."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Langsam B."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Sabile A.A."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/author | "Aemisegger C."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/pages | "1173-1182"xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/title | "Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice."xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://purl.uniprot.org/core/volume | "1832"xsd:string |
| http://purl.uniprot.org/citations/23528710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23528710 |
| http://purl.uniprot.org/citations/23528710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23528710 |
| http://purl.uniprot.org/uniprot/#_A1L0T9-mappedCitation-23528710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23528710 |
| http://purl.uniprot.org/uniprot/#_A2BH47-mappedCitation-23528710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23528710 |
| http://purl.uniprot.org/uniprot/#_B3KXU8-mappedCitation-23528710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23528710 |
| http://purl.uniprot.org/uniprot/#_B4DI61-mappedCitation-23528710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23528710 |