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Objective

To investigate the effect of advanced oxidation protein products (AOPP) on proliferation, differentiation, and oxidative stress in rat osteoblasts.

Methods

The cell proliferation and differentiation of osteoblasts isolated from neonatal SD rat skull were evaluated following treatment with different concentrations (50, 100, 200, and 400 µg/ml) of AOPP using CCK-8 kit and ALP assay kit, respectively. The levels of reactive oxygen species (ROS) in the treated cells were analyzed using 2', 7'-dichlorofluorescin diacetate, and the transcription levels of ALP, collagen I and RAGE were assessed using real-time PCR.

Results

Compared with the control group, AOPP-treated osteoblasts showed obviously inhibited proliferation and differentiation with down-regulated expressions of ALP and collagen I and increased ROS production and RAGE expression.

Conclusion

AOPP can inhibit the proliferation and differentiation of rat osteoblasts partially by up-regulating RAGE and inducing ROS production."xsd:string
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http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/author"Zhang Z."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/author"Yang L."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/author"Sun N."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/author"Cai D."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/name"Nan Fang Yi Ke Da Xue Xue Bao"xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/pages"356-359"xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/title"[Advanced oxidation protein products inhibit proliferation and differentiation of rat osteoblasts through oxidative stress]."xsd:string
http://purl.uniprot.org/citations/23529231http://purl.uniprot.org/core/volume"33"xsd:string
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