| http://purl.uniprot.org/citations/23530123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23530123 | http://www.w3.org/2000/01/rdf-schema#comment | "In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor-ligand interactions mediate this process. Whereas Delta-like 4 supports both TCR-αβ and -γδ development, Jagged1 induces mainly αβ-lineage differentiation. In contrast, Jagged2-mediated Notch activation primarily results in γδ T cell development and represses αβ-lineage differentiation by inhibiting TCR-β formation. Consistently, TCR-αβ T cell development is rescued through transduction of a TCR-β transgene. Jagged2 induces the strongest Notch signal through interactions with both Notch1 and Notch3, whereas Delta-like 4 primarily binds Notch1. In agreement, Notch3 is a stronger Notch activator and only supports γδ T cell development, whereas Notch1 is a weaker activator supporting both TCR-αβ and -γδ development. Fetal thymus organ cultures in JAG2-deficient thymic lobes or with Notch3-blocking antibodies confirm the importance of Jagged2/Notch3 signaling in human TCR-γδ differentiation. Our findings reveal that differential Notch receptor-ligand interactions mediate human TCR-αβ and -γδ T cell differentiation and provide a mechanistic insight into the high Notch dependency of human γδ T cell development."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20121798"xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Koch U."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Gridley T."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "De Medts J."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Plum J."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Radtke F."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Leclercq G."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Kerre T."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Snauwaert S."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Vandekerckhove B."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Van de Walle I."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "De Smedt M."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "De Smet G."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Taghon T."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/author | "Waegemans E."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/pages | "683-697"xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/title | "Specific Notch receptor-ligand interactions control human TCR-alphabeta/gammadelta development by inducing differential Notch signal strength."xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://purl.uniprot.org/core/volume | "210"xsd:string |
| http://purl.uniprot.org/citations/23530123 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23530123 |
| http://purl.uniprot.org/citations/23530123 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23530123 |