| http://purl.uniprot.org/citations/23531880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23531880 | http://www.w3.org/2000/01/rdf-schema#comment | "Conditional knock-out (KO) of Polycomb Group (PcG) protein YY1 results in pro-B cell arrest and reduced immunoglobulin locus contraction needed for distal variable gene rearrangement. The mechanisms that control these crucial functions are unknown. We deleted the 25 amino-acid YY1 REPO domain necessary for YY1 PcG function, and used this mutant (YY1ΔREPO), to transduce bone marrow from YY1 conditional KO mice. While wild-type YY1 rescued B-cell development, YY1ΔREPO failed to rescue the B-cell lineage yielding reduced numbers of B lineage cells. Although the IgH rearrangement pattern was normal, there was a selective impact at the Igκ locus that showed a dramatic skewing of the expressed Igκ repertoire. We found that the REPO domain interacts with proteins from the condensin and cohesin complexes, and that YY1, EZH2 and condensin proteins co-localize at numerous sites across the Ig kappa locus. Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Igκ Vκ genes suggesting a direct role for YY1-condensin complexes in Igκ locus structure and rearrangement."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.66"xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Basu A."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Wei F."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Hodawadekar S."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Atchison M.L."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Calamito M."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Zaprazna K."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Cancro M."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Papasani M."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/author | "Quinn Iii W.J."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/pages | "1168-1182"xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/title | "YY1 controls Igkappa repertoire and B-cell development, and localizes with condensin on the Igkappa locus."xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23531880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23531880 |
| http://purl.uniprot.org/citations/23531880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23531880 |