| http://purl.uniprot.org/citations/23536637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23536637 | http://www.w3.org/2000/01/rdf-schema#comment | "Mast cells are well positioned in host tissue for detecting environmental signals, including allergens, leading to activation of the high-affinity IgE receptor FcεRI, and initiating a signaling cascade that perpetuates the production of biologically potent mediators, including chemokines. We have identified a novel target of mast cell FcεRI activity in the transcription factor early growth response 2 (Egr2) and sought to characterize its function therein. Egr2 was transiently activated following FcεRI-mediated signaling, targeted the promoter of the chemokine CCL1, and was critical for allergen-induced mast cell CCL1 production. Egr2-deficient mast cells were incapable of directing CD4(+) T cell migration via the CCL1-CCR8 axis. In a model of allergic asthma, reconstitution of mast cell-deficient mice with Egr2-deficient mast cells demonstrated that mast cell Egr2 was essential for migration of CD4(+) T cells to the inflamed lung. These findings position Egr2 as a critical regulator of mast cell-directed CD4(+) T cell migration."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1203158"xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Berman J.N."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Lin T.J."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Junkins R."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/author | "Macneil A.J."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/pages | "4500-4507"xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/title | "Mast cell FcepsilonRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration."xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://purl.uniprot.org/core/volume | "190"xsd:string |
| http://purl.uniprot.org/citations/23536637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23536637 |
| http://purl.uniprot.org/citations/23536637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23536637 |
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