| http://purl.uniprot.org/citations/23537633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23537633 | http://www.w3.org/2000/01/rdf-schema#comment | "Compartmentalization of RNA biosynthetic factors into nuclear bodies (NBs) is a ubiquitous feature of eukaryotic cells. How NBs initially assemble and ultimately affect gene expression remains unresolved. The histone locus body (HLB) contains factors necessary for replication-coupled histone messenger RNA transcription and processing and associates with histone gene clusters. Using a transgenic assay for ectopic Drosophila HLB assembly, we show that a sequence located between, and transcription from, the divergently transcribed H3-H4 genes nucleates HLB formation and activates other histone genes in the histone gene cluster. In the absence of transcription from the H3-H4 promoter, "proto-HLBs" (containing only a subset of HLB components) form, and the adjacent histone H2a-H2b genes are not expressed. Proto-HLBs also transiently form in mutant embryos with the histone locus deleted. We conclude that HLB assembly occurs through a stepwise process involving stochastic interactions of individual components that localize to a specific sequence in the H3-H4 promoter."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.02.014"xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Marzluff W.F."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Duronio R.J."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Salzler H.R."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "McDaniel S.L."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Tatomer D.C."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Malek P.Y."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/author | "Orlando A.N."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/pages | "623-634"xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/title | "A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs."xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23537633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23537633 |
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