| http://purl.uniprot.org/citations/23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23538750 | http://www.w3.org/2000/01/rdf-schema#comment | "c-MYC (hereafter MYC) overexpression has been recognized in aggressive B-cell lymphomas and linked to adverse prognosis. MYC activation results in widespread repression of micro-RNA (miRNA) expression and associated with lymphoma aggressive progression. Our recent study identified a MYC-miRNA-EZH2 feed-forward loop linking overexpression of MYC, EZH2 and miRNA repression. Here, using a novel small-molecule BET bromodomain inhibitor, JQ1, and the EZH2 inhibitor, DZNep, we demonstrated that combined treatment of JQ1 and DZNep cooperatively disrupted MYC activation, resulting in a greater restoration of miR-26a expression and synergistically suppressed lymphoma growth and clonogenicity in aggressive lymphoma cells. Furthermore, CHIP assay demonstrated that MYC recruited EZH2 to miR-26a promoter and cooperatively repressed miR-26a expression in aggressive lymphoma cell lines, as well as primary lymphoma cells. Loss- or gain-of-function approaches revealed that miR-26a functioned as a tumor suppressor miRNA and mediated the combinatorial effects of JQ1 and DZNep. These findings represent a novel promising approach for silencing MYC-miRNA-EZH2 amplification loop for combinatorial therapy of aggressive B-cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2013.94"xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Huang A."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Tao J."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Marquez V.E."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Chen-Kiang S."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Dalton W.S."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Sotomayor E."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/author | "Lwin T."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/pages | "2341-2350"xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/title | "Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity."xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23538750 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23538750 |
| http://purl.uniprot.org/citations/23538750 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23538750 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23538750 |
| http://purl.uniprot.org/uniprot/#_F2YMM1-mappedCitation-23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23538750 |
| http://purl.uniprot.org/uniprot/#_A0A090N8E9-mappedCitation-23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23538750 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23538750 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-23538750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23538750 |