| http://purl.uniprot.org/citations/23541922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23541922 | http://www.w3.org/2000/01/rdf-schema#comment | "The functions of the Ndc80/Hec1 subunit of the highly conserved Ndc80 kinetochore complex are normally restricted to M phase when it exerts a pivotal kinetochore-based role. Here, we find that in mouse oocytes, depletion of Hec1 severely compromises the G2-M transition because of impaired activation of cyclin-dependent kinase 1 (Cdk1). Unexpectedly, impaired M phase entry is due to instability of the Cdk1-activating subunit, cyclin B2, which cannot be covered by cyclin B1. Hec1 protects cyclin B2 from destruction by the Cdh1-activated anaphase-promoting complex (APC(Cdh1)) and remains important for cyclin B2 stabilization during early M phase, required for the initial stages of acentrosomal spindle assembly. By late M phase, however, Hec1 and cyclin B2 become uncoupled, and although Hec1 remains stable, APC(Cdc20) triggers cyclin B2 destruction. These data identify another dimension to Hec1 function centered on M phase entry and early prometaphase progression and challenge the view that cyclin B2 is completely dispensable in mammals."xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.02.008"xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/author | "Gui L."xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/author | "Homer H."xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/pages | "43-54"xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/title | "Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes."xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23541922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23541922 |
| http://purl.uniprot.org/citations/23541922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23541922 |
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| http://purl.uniprot.org/uniprot/Q9R1K5#attribution-C4779D1D08ED09E1969302E5D6E86C97 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23541922 |
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| http://purl.uniprot.org/uniprot/Q9D0F1#attribution-5082EE3A0EC921EE9C6CCF87BE88B285 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23541922 |
| http://purl.uniprot.org/uniprot/Q9D0F1#attribution-C4779D1D08ED09E1969302E5D6E86C97 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23541922 |
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| http://purl.uniprot.org/uniprot/#_A0A3B2WAS6-mappedCitation-23541922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23541922 |
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| http://purl.uniprot.org/uniprot/#_D3YTV2-mappedCitation-23541922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23541922 |
| http://purl.uniprot.org/uniprot/#_E9QKK1-mappedCitation-23541922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23541922 |