| http://purl.uniprot.org/citations/23545296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23545296 | http://www.w3.org/2000/01/rdf-schema#comment | "To further understand the mechanisms of formalin-inactivated Coxiella burnetii phase I (PI) vaccine (PIV)-induced protection, we examined if B cell, T cell, CD4(+) T cell, or CD8(+) T cell deficiency in mice significantly affects the ability of PIV to confer protection against a C. burnetii infection. Interestingly, compared to wild-type (WT) mice, PIV conferred comparable levels of protection in CD4(+) T cell- or CD8(+) T cell-deficient mice and partial protection in T cell-deficient mice but did not provide measurable protection in B cell-deficient mice. These results suggest that PIV-induced protection depends on B cells. In addition, anti-PI-specific IgM was the major detectable antibody (Ab) in immune sera from PIV-vaccinated CD4(+) T cell-deficient mice, and passive transfer of immune sera from PIV-vaccinated CD4(+) T cell-deficient mice conferred significant protection. These results suggest that T cell-independent anti-PI-specific IgM may contribute to PIV-induced protection. Our results also suggested that PIV-induced protection may not depend on complement activation and Fc receptor-mediated effector functions. Furthermore, our results demonstrated that both IgM and IgG from PIV-vaccinated WT mouse sera were able to inhibit C. burnetii infection in vivo, but only IgM from PIV-vaccinated CD4(+) T cell-deficient mouse sera inhibited C. burnetii infection. Collectively, these findings suggest that PIV-induced protection depends on B cells to produce protective IgM and IgG and that T cell-independent anti-PI-specific IgM may play a critical role in PIV-induced protection against C. burnetii infection."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.00297-13"xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Mitchell W."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Elliott A."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/author | "Schoenlaub L."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/pages | "2112-2122"xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/title | "Formalin-inactivated Coxiella burnetii phase I vaccine-induced protection depends on B cells to produce protective IgM and IgG."xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/23545296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23545296 |
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