| http://purl.uniprot.org/citations/23547098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23547098 | http://www.w3.org/2000/01/rdf-schema#comment | "4-1BB agonist antibody treatment induces a population of KLRG1(+) T cells that infiltrate melanoma tumors. We investigated the origin and function of these cells, as well as their place within established T cell paradigms. We find that these T cells, particularly the CD4 lineage, represent a novel phenotype characterized by enhanced, multipotent cytotoxicity. Distinct from described polarities, this T cell phenotype is driven by the T-box transcription factor Eomesodermin. Formation of this phenotype requires 4-1BB signaling on both T and antigen-presenting cells and the resulting production of the cytokines IL-27, IL-15, and IL-10. Furthermore, we find CD4(+) T cells bearing the signature features of this phenotype in the livers of mice infected with both bacterial and viral intracellular pathogens, suggesting a role for these cells in infectious immunity. These T cells constitute a novel phenotype that resolves multiple questions associated with 4-1BB activation, including how 4-1BB enhances tumor-specific cytotoxicity and how 4-1BB can promote tumor immunity while repressing autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20121190"xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Sun J.C."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Allison J.P."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Geiger T.L."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Al-Shamkhani A."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Curran M.A."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/author | "Montalvo W."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/pages | "743-755"xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/title | "Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin."xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://purl.uniprot.org/core/volume | "210"xsd:string |
| http://purl.uniprot.org/citations/23547098 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23547098 |
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| http://purl.uniprot.org/uniprot/#_A2A887-mappedCitation-23547098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23547098 |
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