| http://purl.uniprot.org/citations/23549083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23549083 | http://www.w3.org/2000/01/rdf-schema#comment | "Molecular mechanisms specific to colitis-associated cancers have been poorly characterized. Using comparative whole-genome expression profiling, we observed differential expression of epiregulin (EREG) in mouse models of colitis-associated, but not sporadic, colorectal cancer. Similarly, EREG expression was significantly upregulated in cohorts of patients with colitis-associated cancer. Furthermore, tumor-associated fibroblasts were identified as a major source of EREG in colitis-associated neoplasms. Functional studies showed that Ereg-deficient mice, although more prone to colitis, were strongly protected from colitis-associated tumors. Serial endoscopic studies revealed that EREG promoted tumor growth rather than initiation. Additionally, we demonstrated that fibroblast-derived EREG requires ERK activation to induce proliferation of intestinal epithelial cells (IEC) and tumor development in vivo. To demonstrate the functional relevance of EREG-producing tumor-associated fibroblasts, we developed a novel system for adoptive transfer of these cells via mini-endoscopic local injection. It was found that transfer of EREG-producing, but not Ereg-deficient, fibroblasts from tumors significantly augmented growth of colitis-associated neoplasms in vivo. In conclusion, our data indicate that EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci63748"xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Becker C."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Klinger P."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Sahin U."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Neurath M.F."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Tureci O."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Threadgill D.W."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Atreya I."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Schneider-Stock R."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Greten F.R."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Neufert C."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Vieth M."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Leppkes M."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Waldner M.J."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Jefremow A."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Backert I."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/author | "Floh K."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/pages | "1428-1443"xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/title | "Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK."xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/23549083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23549083 |