| http://purl.uniprot.org/citations/23550149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23550149 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the galectin family of proteins have been shown to regulate the development and the function of immune cells. We previously identified the increased expression of galectin-1 and galectin-3 mRNA and protein in anergic B cells relative to their naïve counterparts. To investigate the role of these galectins in maintaining B cell tolerance, we crossed mice deficient in galectin-1 or galectin-3 with mice bearing a lupus autoantigen-binding transgenic (Tg) B cell receptor, using a model with a well-characterized B cell tolerance phenotype of deletion, receptor editing and anergy. Here, we present data showing that the global knockout of galectin-1 or galectin-3 yields subtle alterations in B cell fate in autoantibody Tg mice. The absence of galectin-3 leads to a significant increase in the number of Tg spleen B cells, with the recovery of anti-laminin antibodies from a subset of mice. The B cell number increases further in antibody Tg mice with the dual deficiency of both galectin-1 and galectin-3. Isolated galectin-1 deficiency significantly enhances the proliferation of Tg B cells in response to lipopolysaccharide stimulation. These findings add to the growing body of evidence indicating a role for the various galectin family members, and for galectins 1 and 3 in particular, in the regulation of autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.org/dc/terms/identifier | "doi:10.1093/glycob/cwt026"xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/author | "Clark A.G."xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/author | "Foster M.H."xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/author | "Weston M.L."xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/name | "Glycobiology"xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/pages | "893-903"xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/title | "Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model."xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23550149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23550149 |
| http://purl.uniprot.org/citations/23550149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23550149 |
| http://purl.uniprot.org/uniprot/#_D3YVT4-mappedCitation-23550149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23550149 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHJ0-mappedCitation-23550149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23550149 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRE5-mappedCitation-23550149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23550149 |
| http://purl.uniprot.org/uniprot/#_D3YZJ2-mappedCitation-23550149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23550149 |
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