| http://purl.uniprot.org/citations/23552410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23552410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23552410 | http://www.w3.org/2000/01/rdf-schema#comment | "Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Savellini, F. Weber, C. Terrosi, M. Habjan, B. Martorelli, and M. G. Cusi, J. Gen. Virol. 92:71-79, 2011). In this study, we investigated whether an upstream sensor, which has a role in the signaling cascade leading to the production of type I IFN, was involved. We found a significant decrease in RIG-I protein levels in cells overexpressing TOSV NSs, suggesting that the nonstructural protein interacts with RIG-I and targets it for proteasomal degradation. In fact, the MG-132 proteasome inhibitor was able to restore IFN-β promoter activation in cells expressing NSs, demonstrating the existence of an evasion mechanism based on inhibition of the RIG-I sensor. Furthermore, a C-terminal truncated NSs protein (ΔNSs), although able to interact with RIG-I, did not affect the RIG-I-mediated IFN-β promoter activation, suggesting that the NSs domains responsible for RIG-I-mediated signaling and interaction with RIG-I are mapped on different regions. These results contribute to identify a novel mechanism for bunyaviruses by which TOSV NSs counteracts the early IFN response."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.03129-12"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.03129-12"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Cusi M.G."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Cusi M.G."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Gori-Savellini G."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Gori-Savellini G."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Valentini M."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/author | "Valentini M."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/pages | "6660-6667"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/pages | "6660-6667"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/title | "Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/title | "Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/23552410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23552410 |
| http://purl.uniprot.org/citations/23552410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23552410 |
| http://purl.uniprot.org/citations/23552410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23552410 |
| http://purl.uniprot.org/citations/23552410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23552410 |