| http://purl.uniprot.org/citations/23553029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23553029 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to examine the effects of esophageal cancer-related gene 4 (ECRG4) expression levels on chemotherapeutic sensitivity of gastric cancer cells. A SGC-7901 cell system with tetracycline-inducible ECRG4 expression (SGC-7901/ECRG4) was successfully established. ECRG4 mRNA and protein expression levels were detected using quantitative reverse transcription polymerase chain reaction and Western blotting, respectively. Chemosensitivity to 5-fluorouracil (5-FU) was examined by cell proliferation assay and cell apoptosis assay. ECRG4 mRNA and protein expression levels were significantly upregulated in SGC-7901/ECRG4 cells induced with tetracycline. Compared with control cells, the growth inhibition rate of cells with ECRG4 overexpression was significantly increased when treated with 5-FU. Treatment with 5 μmol/l 5-FU resulted in 15.2 % apoptotic cells, whereas such treatment after overexpression of ECRG4 resulted in 44.5 % apoptotic cells. In conclusion, overexpression of ECRG4 enhanced the chemosensitivity of gastric cancer SGC-7901 cells to 5-FU through induction of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-013-0768-1"xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Wang B.Q."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Fu M.Y."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Wu B.H."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/author | "Jiang C.P."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/pages | "2269-2273"xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/title | "Overexpression of ECRG4 enhances chemosensitivity to 5-fluorouracil in the human gastric cancer SGC-7901 cell line."xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23553029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23553029 |
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