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http://purl.uniprot.org/citations/23553334http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23553334http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Solid tumors involve an inflammatory microenvironment portrayed by immune cells playing role in cancer progression via inflammatory p38α mitogen-activated protein kinase (MAPK) molecule that produces pro-inflammatory cytokines-TNFα, IL1β and IL6. This study quantified and compared the expression of p38α in peripheral blood mononuclear cells (PBMCs) of HNSCC patients with the healthy subjects.

Methods

The PBMC were isolated from the 35 control and 83 HNSCC patients. The expression of p38α in PBMCs was assessed using surface plasmon resonance (SPR), ELISA and western blot analysis.

Results

p38α levels were found to be over-expressed in HNSCC patients 0.98 ng/μl (95 % CI 0.95-1.02) as compared to controls 0.46 ng/μl (95 % CI 0.42-0.50) (p < 0.0001).

Conclusion

p38α is over-expressed in PBMCs of HNSCC patients and may play a role in the progression of cancer. This research may translate a protein marker for HNSCC to clinical oncologist for therapeutic intervention and use as a predictive marker."xsd:string
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http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/author"Kumar R."xsd:string
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/author"Dey S."xsd:string
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/author"Gill K."xsd:string
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/author"Mohanti B.K."xsd:string
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/name"Clin Transl Oncol"xsd:string
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http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/title"Assessment of p38alpha in peripheral blood mononuclear cells (PBMC): a potential blood protein marker of head and neck squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/23553334http://purl.uniprot.org/core/volume"15"xsd:string
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