| http://purl.uniprot.org/citations/23554722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23554722 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatase of regenerating liver-3 (PRL-3) is a member of the protein tyrosine phosphatase (PTP) superfamily and is highly expressed in cancer metastases. For better understanding of the role of PRL-3 in tumor metastasis, we applied a rapid and efficient method for generating PRL-3 floxed mice and investigated its phenotypes. A BAC retrieval strategy was applied to construct the PRL-3 conditional gene-targeting vector. Exon 4 was selected for deletion to generate a nonfunctional prematurely terminated short peptide as it will cause a frame-shift mutation. Conditional knockout PRL-3 mice were generated by using the Cre-loxP system and were validated by Southern blot and RT-PCR analysis. Further analysis revealed the phenotype characteristics of PRL-3 knockout mice and wildtype mice. In this study, we successfully constructed the PRL-3 conditional knockout mice, which will be helpful to clarify the roles of PRL-3 and the mechanisms in tumor metastasis."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1674-8301(11)60058-4"xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/author | "Ge X."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/author | "Yan H."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/author | "Kong D."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/name | "J Biomed Res"xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/pages | "438-443"xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/title | "Generation of conditional knockout alleles for PRL-3."xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23554722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23554722 |
| http://purl.uniprot.org/citations/23554722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23554722 |
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| http://purl.uniprot.org/uniprot/#_E9PXS4-mappedCitation-23554722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23554722 |
| http://purl.uniprot.org/uniprot/#_Q4FK37-mappedCitation-23554722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23554722 |
| http://purl.uniprot.org/uniprot/#_Q9D658-mappedCitation-23554722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23554722 |
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