| http://purl.uniprot.org/citations/23569211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23569211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23569211 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA)-I molecules can present long peptides, yet the mechanisms by which T-cell receptors (TCRs) recognize featured pHLA-I landscapes are unclear. We compared the binding modes of three distinct human TCRs, CA5, SB27, and SB47, complexed with a "super-bulged" viral peptide (LPEPLPQGQLTAY) restricted by HLA-B*35:08. The CA5 and SB27 TCRs engaged HLA-B*35:08(LPEP) similarly, straddling the central region of the peptide but making limited contacts with HLA-B*35:08. Remarkably, the CA5 TCR did not contact the α1-helix of HLA-B*35:08. Differences in the CDR3β loop between the CA5 and SB27 TCRs caused altered fine specificities. Surprisingly, the SB47 TCR engaged HLA-B*35:08(LPEP) using a completely distinct binding mechanism, namely "bypassing" the bulged peptide and making extensive contacts with the extreme N-terminal end of HLA-B*35:08. This docking footprint included HLA-I residues not observed previously as TCR contact sites. The three TCRs exhibited differing patterns of alloreactivity toward closely related or distinct HLA-I allotypes. Thus, the human T-cell repertoire comprises a range of TCRs that can interact with "bulged" pHLA-I epitopes using unpredictable strategies, including the adoption of atypical footprints on the MHC-I."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.447185"xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.447185"xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Burrows S.R."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Burrows S.R."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Liu Y.C."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Liu Y.C."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Neller M.A."xsd:string |
| http://purl.uniprot.org/citations/23569211 | http://purl.uniprot.org/core/author | "Neller M.A."xsd:string |