| http://purl.uniprot.org/citations/23572076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23572076 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycerol-3-phosphate acyltransferase (GPAT) is involved in the first step in glycerolipid synthesis and is localized in both the endoplasmic reticulum (ER) and mitochondria. To clarify the functional differences between ER-GPAT and mitochondrial (Mt)-GPAT, we generated both GPAT mutants in C. elegans and demonstrated that Mt-GPAT is essential for mitochondrial fusion. Mutation of Mt-GPAT caused excessive mitochondrial fragmentation. The defect was rescued by injection of lysophosphatidic acid (LPA), a direct product of GPAT, and by inhibition of LPA acyltransferase, both of which lead to accumulation of LPA in the cells. Mitochondrial fragmentation in Mt-GPAT mutants was also rescued by inhibition of mitochondrial fission protein DRP-1 and by overexpression of mitochondrial fusion protein FZO-1/mitofusin, suggesting that the fusion/fission balance is affected by Mt-GPAT depletion. Mitochondrial fragmentation was also observed in Mt-GPAT-depleted HeLa cells. A mitochondrial fusion assay using HeLa cells revealed that Mt-GPAT depletion impaired mitochondrial fusion process. We postulate from these results that LPA produced by Mt-GPAT functions not only as a precursor for glycerolipid synthesis but also as an essential factor of mitochondrial fusion."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.77"xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Arai H."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Aoki J."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Inoue A."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Kage-Nakadai E."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Tomioka N.H."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Ishihara N."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Sakuragi T."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Imae R."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/author | "Kono N."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/pages | "1265-1279"xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/title | "Mitochondria-type GPAT is required for mitochondrial fusion."xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23572076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23572076 |
| http://purl.uniprot.org/citations/23572076 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23572076 |
| http://purl.uniprot.org/uniprot/Q22949#attribution-8262FBB4BFFB5BEC778892A05C0B31F5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23572076 |
| http://purl.uniprot.org/uniprot/Q21812#attribution-8262FBB4BFFB5BEC778892A05C0B31F5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23572076 |
| http://purl.uniprot.org/uniprot/Q1ZXU8#attribution-8262FBB4BFFB5BEC778892A05C0B31F5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23572076 |