| http://purl.uniprot.org/citations/23576681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23576681 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of surface-bound TGF-β on regulatory T cells (Tregs) and the mechanisms that mediate its functions are not well defined. We recently identified a cell-surface molecule called Glycoprotein A Repetitions Predominant (GARP), which is expressed specifically on activated Tregs and was found to bind latent TGF-β and mediate a portion of Treg suppressive activity in vitro. In this article, we address the role of GARP in regulating Treg and conventional T cell development and immune suppression in vivo using a transgenic mouse expressing GARP on all T cells. We found that, despite forced expression of GARP on all T cells, stimulation through the TCR was required for efficient localization of GARP to the cell surface. In addition, IL-2 signals enhanced GARP cell surface expression specifically on Tregs. GARP-transgenic CD4(+) T cells and Tregs, especially those expressing higher levels of GARP, were significantly reduced in the periphery. Mature Tregs, but not conventional CD4(+) T cells, were also reduced in the thymus. CD4(+) T cell reduction was more pronounced within the effector/memory subset, especially as the mouse aged. In addition, GARP-overexpressing CD4(+) T cells stimulated through the TCR displayed reduced proliferative capacity, which was restored by inhibiting TGF-β signaling. Furthermore, inhibiting TGF-β signals greatly enhanced surface expression of GARP on Tregs and blocked the induction of Foxp3 in activated CD4(+) T cells overexpressing GARP. These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-β and signaling, which negatively regulates GARP expression on Tregs."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300065"xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/author | "Unutmaz D."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/author | "Kozhaya L."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/author | "Zhou A.X."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/pages | "5057-5064"xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/title | "GARP-TGF-beta complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://purl.uniprot.org/core/volume | "190"xsd:string |
| http://purl.uniprot.org/citations/23576681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23576681 |
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