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| http://purl.uniprot.org/citations/23578839 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain-derived neurotrophic factor (BDNF) is a crucial regulator of neuroplasticity, which underlies learning and memory processes in different brain areas. To investigate the role of BDNF in the extinction of amygdala-dependent cued fear memories, we analyzed fear extinction learning in heterozygous BDNF knock-out mice, which possess a reduction of endogenous BDNF protein levels to ~50% of wild-type animals. Since BDNF expression has been shown to decline with aging of animals, we tested the performance in extinction learning of these mice at 2 months (young adults) and 7 months (older adults) of age. The present study shows that older adult heterozygous BDNF knock-out mice, which have a chronic 50% lack of BDNF, also possess a deficit in the acquisition of extinction memory, while extinction learning remains unaffected in young adult heterozygous BDNF knock-out mice. This deficit in extinction learning is accompanied by a reduction of BDNF protein in the hippocampus, amygdala and the prefrontal cortex."xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nlm.2013.03.003"xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/author | "Lessmann V."xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/author | "Endres T."xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/author | "Psotta L."xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/name | "Neurobiol Learn Mem"xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/pages | "34-38"xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/title | "Impaired fear extinction learning in adult heterozygous BDNF knock-out mice."xsd:string |
| http://purl.uniprot.org/citations/23578839 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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