| http://purl.uniprot.org/citations/23584088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23584088 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelets have a key role in atherogenesis and its complications. Both hypercholesterolemia and increased platelet production promote atherothrombosis; however, a potential link between altered cholesterol homeostasis and platelet production has not been explored. Here we show that transplantation of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis. Although not detected in atherosclerotic lesions, Abcg4 was highly expressed in bone marrow megakaryocyte progenitors (MkPs). Abcg4(-/-) MkPs had defective cholesterol efflux to high-density lipoprotein (HDL), increased cell surface expression of the thrombopoietin (TPO) receptor (c-MPL) and enhanced proliferation. These consequences of ABCG4 deficiency seemed to reflect disruption of negative feedback regulation of c-MPL signaling by the E3 ligase c-CBL and the cholesterol-sensing LYN kinase. HDL infusion reduced platelet counts in Ldlr(-/-) mice and in a mouse model of myeloproliferative neoplasm in an ABCG4-dependent fashion. HDL infusions may offer a new approach to reducing atherothrombotic events associated with increased platelet production."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3150"xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Tall A.R."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Ni H."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Yvan-Charvet L."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Bhagwat N."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Murphy A.J."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Levine R.L."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Shaw J.A."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Reheman A."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Bijl N."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/author | "Welch C.B."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/pages | "586-594"xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/title | "Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis."xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/23584088 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23584088 |
| http://purl.uniprot.org/citations/23584088 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23584088 |
| http://purl.uniprot.org/uniprot/#_E0CY02-mappedCitation-23584088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23584088 |
| http://purl.uniprot.org/uniprot/#_E0CYI8-mappedCitation-23584088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23584088 |
| http://purl.uniprot.org/uniprot/#_Q0VDW9-mappedCitation-23584088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23584088 |