| http://purl.uniprot.org/citations/23585135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23585135 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet-derived growth factor (PDGF)-D is a newly recognized member of the PDGF family with its role just now being understood. Our previous study shows that PDGF-D and its receptors (PDGFR-β) are significantly increased in the infarcted heart, where PDGFR-β is primarily expressed by fibroblasts, indicating the involvement of PDGF-D in the development of cardiac fibrosis. In continuing with these findings, the current study explored the molecular basis of PDGF-D on fibrogenesis. Rat cardiac fibroblasts were isolated and treated with PDGF-D (200 ng/ml medium). The potential regulation of PDGF-D on fibroblast growth, phenotype change, collagen turnover, and the transforming growth factor (TGF)-β pathway were explored. We found: 1) PDGF-D significantly elevated cardiac fibroblast proliferation, myofibroblast (myoFb) differentiation, and type I collagen secretion; 2) matrix metalloproteinase (MMP)-1, MMP-2, and MMP-9 protein levels were significantly elevated in PDGF-D-treated cells, which were coincident with increased expressions of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2; 3) PDGF-D significantly enhanced TGF-β1 synthesis, which was eliminated by TGF-β blockade with small-interfering RNA (siRNA); 4) the stimulatory role of PDGF-D on fibroblast proliferation and collagen synthesis was abolished by TGF-β blockade; and 5) TGF-β siRNA treatment significantly suppressed PDGF-D synthesis in fibroblasts. These observations indicate that PDGF-D promotes fibrogenesis through multiple mechanisms. Coelevations of TIMPs and MMPs counterbalance collagen degradation. The profibrogenic role of PDGF-D is mediated through activation of the TGF-β1 pathway. TGF-β1 exerts positive feedback on PDGF-D synthesis. These findings suggest the potential therapeutic effect of PDGFR blockade on interstitial fibrosis in the infarcted heart."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00130.2013"xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Meng W."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Zhao T."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/author | "Li V.S."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/pages | "H1719-26"xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/title | "Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/23585135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23585135 |
| http://purl.uniprot.org/citations/23585135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23585135 |
| http://purl.uniprot.org/uniprot/Q9EQT1#attribution-C93D79B025CC7C23D5382549DAF4ADD0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23585135 |
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| http://purl.uniprot.org/uniprot/#_Q9EQT1-mappedCitation-23585135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23585135 |
| http://purl.uniprot.org/uniprot/Q9EQT1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23585135 |
| http://purl.uniprot.org/uniprot/A0A096MJ33 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23585135 |