| http://purl.uniprot.org/citations/23588310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23588310 | http://www.w3.org/2000/01/rdf-schema#comment | "The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ). Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers for CBZ hypersensitivity in Asian and European patients. To replicate these genetic associations in pediatric patients from North America with a diverse ethnic background, we investigated HLA-A 31:01 and HLA-B 15:02 in 42 children with CBZ hypersensitivity and 91 CBZ-tolerant children from across Canada. HLA-A 31:01 was significantly associated with CBZ-HSS (odds ratio (OR): 26.4, P = 0.0025) and maculopapular exanthema (MPE) (OR: 8.6, P = 0.0037) but not with CBZ-SJS. Conversely, HLA-B 15:02 was associated with CBZ-SJS (OR: 38.6, P = 0.002) but not HSS or MPE. This study is the first to demonstrate the association of HLA-A 31:01 with CBZ hypersensitivity in children, providing important replication of this association and highlighting the importance of HLA-A 31:01 as a predictive biomarker across various ancestries."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.org/dc/terms/identifier | "doi:10.1038/clpt.2013.55"xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Inoue M."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Ogawa M."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "O'Connor L."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Chan S."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Kamiya T."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Ross C.J."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Hayden M.R."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Sakaguchi S."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Carter C."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Rieder M.J."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Wong E."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Maher M."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Wilson B."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Stevenson P."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Hall K."xsd:string |
| http://purl.uniprot.org/citations/23588310 | http://purl.uniprot.org/core/author | "Miao F."xsd:string |