| http://purl.uniprot.org/citations/23591791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23591791 | http://www.w3.org/2000/01/rdf-schema#comment | "TCL1 oncogene is overexpressed in aggressive form of human chronic lymphocytic leukemia (CLL) and its dysregulation in mouse B cells causes a CD5-positive leukemia similar to the aggressive form of human CLLs. To identify oncogenes that cooperate with Tcl1, we performed genetic screen in Eμ-TCL1 mice using Sleeping Beauty transposon-mediated mutagenesis. Analysis of transposon common insertion sites identified 7 genes activated by transposon insertions. Overexpression of these genes in mouse CLL was confirmed by real time reverse transcription-polymerase chain reaction. Interestingly, the main known function of 4 of 7 genes (Nfkb1, Tab2, Map3K14, and Nfkbid) is participation in or activation of the nuclear factor-kB (NF-kB) pathway. In addition, activation of the NF-kB is 1 of main functions of Akt2, also identified in the screen. These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive CLL. Identification cooperating cancer genes will result in the development of combinatorial therapies to treat CLL."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-02-486035"xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Burch A."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Pekarsky Y."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Palamarchuk A."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Zanesi N."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Dupuy A.J."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Lagana A."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Rizzotto L."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Balatti V."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Cascione L."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/author | "Riordan J."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/pages | "4355-4358"xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/title | "A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model."xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/23591791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23591791 |
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| http://purl.uniprot.org/uniprot/#_H3BJA0-mappedCitation-23591791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23591791 |