| http://purl.uniprot.org/citations/23591820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23591820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23591820 | http://www.w3.org/2000/01/rdf-schema#comment | "In eukaryotes, mRNA export involves many evolutionarily conserved factors that carry the nascent transcript to the nuclear pore complex (NPC). The THO/TREX complex couples transcription to mRNA export and recruits the mRNA export receptor NXF1 for the transport of messenger ribonucleoprotein particles (mRNP) to the NPC. The transcription and export complex 2 (TREX-2) was suggested to interact with NXF1 and to shuttle between transcription sites and the NPC. Here, we characterize the dynamics of human TREX-2 and show that it stably associates with the NPC basket. Moreover, the association of TREX-2 with the NPC requires the basket nucleoporins NUP153 and TPR, but is independent of transcription. Differential profiles of mRNA nuclear accumulation reveal that TREX-2 functions similarly to basket nucleoporins, but differently from NXF1. Thus, our results show that TREX-2 is an NPC-associated complex in mammalian cells and suggest that it is involved in putative NPC basket-related functions."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.118000"xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.118000"xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Fischer B."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Fischer B."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Tora L."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Tora L."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Devys D."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Devys D."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Bonnet J."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Bonnet J."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Stierle M."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Stierle M."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Umlauf D."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Umlauf D."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Waharte F."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Waharte F."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Brino L."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Brino L."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Fournier M."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/author | "Fournier M."xsd:string |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23591820 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |