DESCRIBE <http://purl.uniprot.org/citations/23592700>

Subject	Predicate	Object
http://purl.uniprot.org/citations/23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23592700	http://www.w3.org/2000/01/rdf-schema#comment	" Background To investigate the role of Cullin1 (Cul1) in the development of breast cancer, we examined the expression of Cul1 in breast cancer tissues and analyzed the correlation between Cul1 expression and clinicopathologic variables and patients survival. Patients and methods We evaluated the Cul1 expression by immunohistochemistry using a tissue microarray (TMA) which includes 393 breast cancer tissues. We also studied the role of Cul1 in breast cancer cell proliferation, migration and invasion by carrying out CCK8 cell proliferation assay, cell migration and invasion assay. Results The Cul1 expression was significantly correlated with breast cancer histology grade (P = 0.000), estrogen receptor status (P = 0.001), progesterone receptor status (P = 0.001) and human epidermal growth factor receptor 2 status (P = 0.002). Furthermore, we showed a strong correlation between high Cul1 expression and worse 5-year overall and disease-specific survival rates in breast cancer patients (P = 0.026 and P = 0.015, respectively). Finally, we found that Cul1 knockdown inhibits cell proliferation, migration and invasion abilities. Conclusions Cul1 overexpression is significantly correlated with breast cancer progression and predicts worse survival. Cul1 regulates breast cancer cell proliferation, migration and invasion."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.org/dc/terms/identifier	"doi:10.1093/annonc/mdt147"xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Li C."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Liu H."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Wu Y.P."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Bai J."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Chen F.F."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Pan Z.Q."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Zheng J.N."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Mei P.J."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/author	"Yong H.M."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/date	"2013"xsd:gYear
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/name	"Ann Oncol"xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/pages	"2016-2022"xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/title	"Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer."xsd:string
http://purl.uniprot.org/citations/23592700	http://purl.uniprot.org/core/volume	"24"xsd:string
http://purl.uniprot.org/citations/23592700	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/23592700
http://purl.uniprot.org/citations/23592700	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/23592700
http://purl.uniprot.org/uniprot/#_A0A090N7U0-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700
http://purl.uniprot.org/uniprot/#_B3KTW0-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700
http://purl.uniprot.org/uniprot/#_B3KU45-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700
http://purl.uniprot.org/uniprot/#_B4DLA3-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700
http://purl.uniprot.org/uniprot/#_Q13616-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700
http://purl.uniprot.org/uniprot/#_Q75MQ1-mappedCitation-23592700	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23592700