| http://purl.uniprot.org/citations/23593018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23593018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23593018 | http://www.w3.org/2000/01/rdf-schema#comment | "DJ-1, a Parkinson's disease (PD)-associated gene, has been shown to protect against oxidative stress in Drosophila. However, the molecular mechanism underlying oxidative stress-induced phenotypes, including apoptosis, locomotive defects, and lethality, in DJ-1-deficient flies is not fully understood. Here we showed that Daxx-like protein (DLP), a Drosophila homologue of the mammalian Death domain-associated protein (Daxx), was upregulated under oxidative stress conditions in the loss-of-function mutants of Drosophila DJ-1β, a Drosophila homologue of DJ-1. DLP overexpression induced apoptosis via the c-Jun N-terminal kinase (JNK)/Drosophila forkhead box subgroup O (dFOXO) pathway, whereas loss of DLP increased resistance to oxidative stress and UV irradiation. Moreover, the oxidative stress-induced phenotypes of DJ-1β mutants were dramatically rescued by DLP deficiency, suggesting that enhanced expression of DLP contributes to the DJ-1β mutant phenotypes. Interestingly, we found that dFOXO was required for the increase in DLP expression in DJ-1β mutants and that dFOXO activity was increased in the heads of DJ-1β mutants. In addition, subcellular localization of DLP appeared to be influenced by DJ-1 expression so that cytosolic DLP was increased in DJ-1β mutants. Similarly, in mammalian cells, Daxx translocation from the nucleus to the cytosol was suppressed by overexpressed DJ-1β under oxidative stress conditions; and, furthermore, targeted expression of DJ-1β to mitochondria efficiently inhibited the Daxx translocation. Taken together, our findings demonstrate that DJ-1β protects flies against oxidative stress- and UV-induced apoptosis by regulating the subcellular localization and gene expression of DLP, thus implying that Daxx-induced apoptosis is involved in the pathogenesis of DJ-1-associated PD."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003412"xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003412"xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee I.S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Lee I.S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Jeong G."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Jeong G."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Choi G."xsd:string |
| http://purl.uniprot.org/citations/23593018 | http://purl.uniprot.org/core/author | "Choi G."xsd:string |