| http://purl.uniprot.org/citations/23594878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23594878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23594878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23594878 | http://www.w3.org/2000/01/rdf-schema#comment | "The 2 465 177 bp genome of Sulfolobus islandicus LAL14/1, host of the model rudivirus SIRV2, was sequenced. Exhaustive comparative genomic analysis of S. islandicus LAL14/1 and the nine other completely sequenced S. islandicus strains isolated from Iceland, Russia and USA revealed a highly syntenic common core genome of approximately 2 Mb and a long hyperplastic region containing most of the strain-specific genes. In LAL14/1, the latter region is enriched in insertion sequences, CRISPR (clustered regularly interspaced short palindromic repeats), glycosyl transferase genes, toxin-antitoxin genes and MITE (miniature inverted-repeat transposable elements). The tRNA genes of LAL14/1 are preferential targets for the integration of mobile elements but clusters of atypical genes (CAG) are also integrated elsewhere in the genome. LAL14/1 carries five CRISPR loci with 10 per cent of spacers matching perfectly or imperfectly the genomes of archaeal viruses and plasmids found in the Icelandic hot springs. Strikingly, the CRISPR_2 region of LAL14/1 carries an unusually long 1.9 kb spacer interspersed between two repeat regions and displays a high similarity to pING1-like conjugative plasmids. Finally, we have developed a genetic system for S. islandicus LAL14/1 and created ΔpyrEF and ΔCRISPR_1 mutants using double cross-over and pop-in/pop-out approaches, respectively. Thus, LAL14/1 is a promising model to study virus-host interactions and the CRISPR/Cas defence mechanism in Archaea."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.130010"xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.130010"xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.130010"xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Forterre P."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Forterre P."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Forterre P."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Krupovic M."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Krupovic M."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Krupovic M."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Prangishvili D."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Prangishvili D."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Prangishvili D."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "She Q."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "She Q."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "She Q."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Sezonov G."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Sezonov G."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Sezonov G."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Oberto J."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Oberto J."xsd:string |
| http://purl.uniprot.org/citations/23594878 | http://purl.uniprot.org/core/author | "Oberto J."xsd:string |