| http://purl.uniprot.org/citations/23599147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23599147 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated a high specificity of immunohistochemistry using epidermal growth factor receptor (EGFR) mutation-specific antibodies in lung adenocarcinoma and correlation with EGFR mutation analysis. In this study, we assessed EGFR mutation status by immunohistochemistry in a variety of extrapulmonary malignancies, especially those that frequently show EGFR overexpression. Tissue microarrays containing triplicate cores of breast carcinomas (n=300), colorectal carcinomas (n=65), pancreatic adenocarcinoma (n=145), and uterine carcinosarcoma or malignant mixed müllerian tumors (n=25) were included in the study. Tissue microarray of lung adenocarcinoma with known EGFR mutation status was used as reference. Immunohistochemistry was performed using antibodies specific for the E746-A750del and L858R mutations. In pulmonary adenocarcinoma, a staining intensity of 2+ or 3+ correlates with mutation status and is therefore considered as positive. Out of 300 breast carcinomas, 293 (98%) scored 0, 5 (2%) had 1+ staining, 2 (1%) were 2+ for the L858R antibody. All breast carcinomas scored 0 with the E746-A750 antibody. All the colorectal, pancreatic carcinomas and malignant mixed müllerian tumors were negative (0) for both antibodies. Molecular analysis of the breast carcinomas that scored 2+ for L858R showed no mutation. Our results show that EGFR mutation-specific antibodies could be an additional tool distinguishing primary versus metastatic carcinomas in the lung. False-positivity can be seen in breast carcinoma but is extremely rare (1%)."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.org/dc/terms/identifier | "doi:10.1038/modpathol.2013.53"xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Ladanyi M."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Shia J."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Moreira A.L."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Wen Y.H."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Soslow R.A."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Brogi E."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Chitale D."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/author | "Hasanovic A."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/name | "Mod Pathol"xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/pages | "1197-1203"xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/title | "Immunohistochemical staining with EGFR mutation-specific antibodies: high specificity as a diagnostic marker for lung adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/23599147 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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