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| http://purl.uniprot.org/citations/23600770 | http://www.w3.org/2000/01/rdf-schema#comment | "The novel aroylthiourea analogue of podophyllotoxin HY-1 (4β-[benzoyl-thioureido]-4-deoxypodophyllotoxin) was synthesized in our laboratory with the aim of developing multitargeted DNA topoisomerase II inhibitors. The compound showed significant antiproliferative effects on seven cancer cell lines and induced G2 /M phase arrest in HCT116 cells. Moreover, HY-1 showed a potent inhibitory effect on topoisomerase II-mediated kinetoplast DNA decatenation in a dose-dependent manner. Our results showed that cdc2 phosphorylation and decreased cdc2 kinase acitivity through the ATR-Chk1-Cdc25C and Weel pathways were the central mechanisms for G2 /M phase arrest in human colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.12182"xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/pages | "1062-1066"xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/title | "HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways."xsd:string |
| http://purl.uniprot.org/citations/23600770 | http://purl.uniprot.org/core/volume | "104"xsd:string |
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