| http://purl.uniprot.org/citations/23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23602409 | http://www.w3.org/2000/01/rdf-schema#comment | "IκB kinase α (IKKα) activity is required for ErbB2-induced mammary tumorigenesis. Here, we show that IKKα and its activator, NF-κB-inducing kinase (NIK), support the expansion of tumor-initiating cells (TICs) that copurify with a CD24(med)CD49f(hi) population from premalignant ErbB2-expressing mammary glands. Upon activation, IKKα enters the nucleus, phosphorylates the cyclin-dependent kinase (CDK) inhibitor p27/Kip1, and stimulates its nuclear export or exclusion. Reduced p27 expression rescues mammary tumorigenesis in mice deficient in IKKα kinase activity and restores TIC self-renewal. IKKα is also likely to be involved in human breast cancer, where its expression shows an inverse correlation with metastasis-free survival, and its presence in the nucleus of invasive ductal carcinomas (IDCs) is associated with decreased nuclear p27 abundance."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.03.012"xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Ghassemian M."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Tan W."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Poustovoitov M."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Borcherding N."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/author | "Strasner A."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/pages | "647-659"xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/title | "A NIK-IKKalpha module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1."xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23602409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23602409 |
| http://purl.uniprot.org/citations/23602409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23602409 |
| http://purl.uniprot.org/uniprot/#_E9Q605-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |
| http://purl.uniprot.org/uniprot/#_A0AUV3-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |
| http://purl.uniprot.org/uniprot/#_E9QNL4-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |
| http://purl.uniprot.org/uniprot/#_O15111-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |
| http://purl.uniprot.org/uniprot/#_P25963-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |
| http://purl.uniprot.org/uniprot/#_Q3U2A3-mappedCitation-23602409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23602409 |