| http://purl.uniprot.org/citations/23604319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23604319 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses, but despite its importance little is known about how it regulates its target genes. Proteomic identification of DAF-16/FOXO-binding partners in Caenorhabditis elegans and their subsequent functional evaluation by RNA interference revealed several candidate DAF-16/FOXO cofactors, most notably the chromatin remodeller SWI/SNF. DAF-16/FOXO and SWI/SNF form a complex and globally co-localize at DAF-16/FOXO target promoters. We show that specifically for gene activation, DAF-16/FOXO depends on SWI/SNF, facilitating SWI/SNF recruitment to target promoters, to activate transcription by presumed remodelling of local chromatin. For the animal, this translates into an essential role for SWI/SNF in DAF-16/FOXO-mediated processes, in particular dauer formation, stress resistance and the promotion of longevity. Thus, we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2720"xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Asara J.M."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Riedel C.G."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Dillin A."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Kirienko N.V."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Kingston R.E."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "West J.A."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Bowman S.K."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Dowen R.H."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Heimbucher T."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/author | "Lourenco G.F."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/pages | "491-501"xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/title | "DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity."xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/23604319 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23604319 |
| http://purl.uniprot.org/citations/23604319 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23604319 |
| http://purl.uniprot.org/uniprot/#_A0A131MBI3-mappedCitation-23604319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23604319 |
| http://purl.uniprot.org/uniprot/#_A0A131MCF2-mappedCitation-23604319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23604319 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUC0-mappedCitation-23604319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23604319 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUC2-mappedCitation-23604319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23604319 |