| http://purl.uniprot.org/citations/23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23609009 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeThis study retrospectively assessed the mutations of the epidermal growth factor receptor (EGFR) and K-ras genes and their clinical significance in patients with resected stage I adenocarcinomas.MethodsA total of 354 patients with resected lung adenocarcinomas were included, and 256 patients with stage I disease were analyzed for the prognostic and predictive value of these mutations.ResultsMutations of EGFR and K-ras genes were detected in 149 (41.1 %) and 23 (6.4 %) of all tumors, and in 122 (47.6 %) and 14 (5.5 %) of stage I tumors, respectively. There were no significant differences in the disease-free survival (DFS) and overall survival (OS) between the EGFR-mutant and wild-type groups. However, the DFS and OS were significantly shorter in patients with K-ras mutations than in those without (5-year DFS: 50.8 vs. 76.9 %, 5-year OS: 70.0 vs. 86.6 %, p < 0.01). A multivariate analysis showed that K-ras mutations were an independent poor prognostic factor. Twenty-four of the 41 patients with recurrent disease after surgery were treated with an EGFR-TKI. Fifteen EGFR-mutant patients treated with an EGFR-TKI had a better prognosis than did the nine EGFR-wild-type patients.ConclusionThe presence of an EGFR gene mutation was a predictive factor for the response to EGFR-TKI treatment in patients with resected stage I adenocarcinoma, but was not a prognostic factor. The presence of a K-ras gene mutation was a poor prognostic factor."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00595-013-0589-2"xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Ohba T."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Yamaguchi M."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Seto T."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Ichinose Y."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Toyokawa G."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Sugio K."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Hamatake M."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Kometani T."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Hirai F."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/author | "Nosaki K."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/name | "Surg Today"xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/pages | "478-486"xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/title | "Mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance."xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/23609009 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23609009 |
| http://purl.uniprot.org/citations/23609009 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23609009 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23609009 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ1-mappedCitation-23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23609009 |
| http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23609009 |
| http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23609009 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F8-mappedCitation-23609009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23609009 |