| http://purl.uniprot.org/citations/23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23610406 | http://www.w3.org/2000/01/rdf-schema#comment | "Memory is initially labile and gradually consolidated over time through new protein synthesis into a long-lasting stable form. Studies of odor-shock associative learning in Drosophila have established the mushroom body (MB) as a key brain structure involved in olfactory long-term memory (LTM) formation. Exactly how early neural activity encoded in thousands of MB neurons is consolidated into protein-synthesis-dependent LTM remains unclear. Here, several independent lines of evidence indicate that changes in two MB vertical lobe V3 (MB-V3) extrinsic neurons are required and contribute to an extended neural network involved in olfactory LTM: (i) inhibiting protein synthesis in MB-V3 neurons impairs LTM; (ii) MB-V3 neurons show enhanced neural activity after spaced but not massed training; (iii) MB-V3 dendrites, synapsing with hundreds of MB α/β neurons, exhibit dramatic structural plasticity after removal of olfactory inputs; (iv) neurotransmission from MB-V3 neurons is necessary for LTM retrieval; and (v) RNAi-mediated down-regulation of oo18 RNA-binding protein (involved in local regulation of protein translation) in MB-V3 neurons impairs LTM. Our results suggest a model of long-term memory formation that includes a systems-level consolidation process, wherein an early, labile olfactory memory represented by neural activity in a sparse subset of MB neurons is converted into a stable LTM through protein synthesis in dendrites of MB-V3 neurons synapsed onto MB α lobes."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1216336110"xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Lin H.H."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Tully T."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Lee P.T."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Lai J.S."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Chiang A.S."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Pai T.P."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/author | "Chin A.L."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/pages | "7898-7903"xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/title | "Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation."xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23610406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23610406 |
| http://purl.uniprot.org/citations/23610406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFN9-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX7-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFF0-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K612-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K618-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGP6-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |
| http://purl.uniprot.org/uniprot/#_A0A126GUS7-mappedCitation-23610406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23610406 |