| http://purl.uniprot.org/citations/23615404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23615404 | http://www.w3.org/2000/01/rdf-schema#comment | "The POU transcription factor OCT4 is a pleiotropic regulator of gene expression in embryonic stem cells. Recent studies demonstrated that OCT4 is aberrantly expressed in multiple types of human cancer; however, the underlying molecular mechanism remains largely unknown. In this study, we report that OCT4-pg4, a pseudogene of OCT4, is abnormally activated in hepatocellular carcinoma (HCC). The expression level of OCT4-pg4 is positively correlated with that of OCT4, and both gene transcripts can be directly targeted by a tumor-suppressive micro RNA miR-145. We find that the non-coding RNA OCT4-pg4 is biologically active, as it can upregulate OCT4 protein level in HCC. Mechanistic analysis revealed that OCT4-pg4 functions as a natural micro RNA sponge to protect OCT4 transcript from being inhibited by miR-145. In addition, our study also showed that OCT4-pg4 can promote growth and tumorigenicity of HCC cells, thus exerting an oncogenic role in hepatocarcinogenesis. Furthermore, survival analysis suggests that high OCT4-pg4 level is significantly correlated with poor prognosis of HCC patients. Taken together, our finding adds a new layer of post-transcriptional regulation of OCT4 and sheds new light on the treatment of human HCC."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgt139"xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Yang A.G."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Yao L.B."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Xin B."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Guo Z.Y."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Wen W.H."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/author | "Jia L.T."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/pages | "1773-1781"xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/title | "Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23615404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23615404 |
| http://purl.uniprot.org/citations/23615404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23615404 |
| http://purl.uniprot.org/uniprot/#_F2Z381-mappedCitation-23615404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23615404 |
| http://purl.uniprot.org/uniprot/#_D5K9R7-mappedCitation-23615404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23615404 |
| http://purl.uniprot.org/uniprot/#_D5K9R8-mappedCitation-23615404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23615404 |
| http://purl.uniprot.org/uniprot/#_D5K9R9-mappedCitation-23615404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23615404 |