| http://purl.uniprot.org/citations/23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23618358 | http://www.w3.org/2000/01/rdf-schema#comment | "Uterine carcinosarcomas (U-CSs) are considered monoclonal in origin, but little is known about the mechanisms for establishment of heterologous sarcomatous components. Here, we examine the functional roles of nuclear factor κB (NF-κB)/p65 and Sox9 in the transcriptional regulation of alpha-1 type II collagen (COL2A1), a hallmark of chondrogenesis, during morphologic change in the direction of the chondrocytic phenotype. In 32 cases of U-CS, both phosphorylated p65 and Sox9 expression were colocalized in Col2A1-positive sarcomatous components, particularly in cartilaginous elements, with strongly positive correlation (ρ = 0.72, P = .005). A positive association of Col2A1 expression between protein (immunohistochemistry) and messenger RNA (in situ hybridization) assays was evident in sarcomatous components, whereas 9 cases also showed distinct positive signals for the messenger RNA without protein expression in carcinomatous elements, probably through a posttranscriptional and/or posttranslational modulation mechanism. In the Ishikawa endometrial cancer line, overexpression of p65 could activate transcription of COL2A1 promoter-intron reporters through binding to specific NF-κB sites in the first intron, along with up-regulation of Sox9. Exogenous induction of Sox9 also caused an increase in transcription of COL2A1, in contrast to a repression of the p65-mediated COL2A1 transcription, suggesting the existence of a negative feedback loop. These data, therefore, suggest that NF-κB/p65 signaling, as well as Sox9, may contribute to changes in the morphology of U-CS cells toward the chondrocytic phenotype through modulation of COL2A1 transcription."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humpath.2012.12.019"xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Kuwata T."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Inukai M."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Hashimura M."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Saegusa M."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/author | "Tazo Y."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/pages | "1780-1788"xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/title | "Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor B/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas."xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/23618358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23618358 |
| http://purl.uniprot.org/citations/23618358 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23618358 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |
| http://purl.uniprot.org/uniprot/#_A0A0U4U3E8-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |
| http://purl.uniprot.org/uniprot/#_A0A0U4YWA5-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |
| http://purl.uniprot.org/uniprot/#_B4DI77-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-23618358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618358 |