| http://purl.uniprot.org/citations/23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23618918 | http://www.w3.org/2000/01/rdf-schema#comment | "Met/hepatocyte growth factor (HGF) receptor plays a definitive role in hepatocyte proliferation and liver regeneration. Phosphorylation of Ser985 in Met (Met-Ser985) down regulate tyrosine phosphorylation and activation of Met. However, mechanism of Met inactivation by Met-Ser985 phosphorylation and its biological significance on hepatocyte proliferation and liver regeneration are not well known. Here, we investigated biological role of Met-Ser985 phosphorylation in hepatocytes and liver. In primary cultured hepatocytes, HGF-dependent Met activation and mitogenesis were suppressed when Met-Ser985 was phosphorylated. Cell surface Met was decreased upon Met-Ser985 phosphorylation through endocytosis, suggesting a mechanism by which Met activation could be suppressed. In mice, HGF induced proliferation of hepatocyte in injured livers, but not in non-injured livers. Met-Ser985 phosphorylation was decreased after liver injury and associated with Met tyrosine phosphorylation/activation during liver regeneration. These results indicate that Met activation is regulated reciprocally to Met-Ser985 phosphorylation in the primary cultured hepatocytes and the liver following injury. Our study suggests that the phosphorylation of Met-Ser985 in hepatocytes plays a regulatory role in Met activation in response to quiescence, injury, and regeneration."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2013.04.006"xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Sakai K."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/pages | "446-452"xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/title | "Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes."xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/23618918 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23618918 |
| http://purl.uniprot.org/citations/23618918 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23618918 |
| http://purl.uniprot.org/uniprot/#_A1A597-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_A2VCS0-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_A4FUV6-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_A4FUV7-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_F8VQL0-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_P16056-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_Q3TCS4-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_Q6Q531-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |
| http://purl.uniprot.org/uniprot/#_Q6Q532-mappedCitation-23618918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23618918 |