| http://purl.uniprot.org/citations/23622242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23622242 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein interaction. Most importantly, ADAR1 increases the maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role of ADAR1 in miRNA processing and RNAi mechanisms. ADAR1 differentiates its functions in RNA editing and RNAi by the formation of either ADAR1/ADAR1 homodimer or Dicer/ADAR1 heterodimer complexes, respectively. As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.03.024"xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Gupta R."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Sakurai M."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Nishikura K."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Iizasa H."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Ota H."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Valente L."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Ariyoshi K."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Davuluri R.V."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/author | "Wulff B.E."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/pages | "575-589"xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/title | "ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing."xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/23622242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23622242 |
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| http://purl.uniprot.org/uniprot/P55265#attribution-3965D1135404FFDA8DB56D903286882B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23622242 |
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| http://purl.uniprot.org/uniprot/Q99MU3#attribution-6CC94808594AEB8CDA2A459DBCA1F299 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23622242 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J282-mappedCitation-23622242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23622242 |
| http://purl.uniprot.org/uniprot/#_D3Z0J5-mappedCitation-23622242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23622242 |
| http://purl.uniprot.org/uniprot/#_D3Z282-mappedCitation-23622242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23622242 |