http://purl.uniprot.org/citations/23624197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23624197 | http://www.w3.org/2000/01/rdf-schema#comment | "Discs large homolog 1 (DLG1/SAP97) is involved in the development and regulation of neuronal and immunological synapses. DLG1 is a member of the membrane associated guanylate kinase (MAGUK) family of proteins, which function as molecular scaffolds. The C-terminal guanylate kinase (GK) domain of DLG1 binds peptides with a phosphorylated serine residue. In this study, we solved the crystal structure of the GK domain of human DLG1. The C-terminal tail of DLG1 is bound to the peptide-binding site of an adjacent symmetry-related DLG1 GK molecule. The binding direction of the C-terminal tail to the peptide-binding site is opposite to that of the phosphorylated LGN peptide in complex with the rat DLG1 GK domain. The C-terminal tail forms a 310 helix, which is also different from the conformation of the phosphorylated LGN peptide. Nevertheless, the side chain interactions of the C-terminal tail with the DLG1 GK domain are similar to those of the phosphorylated LGN peptide."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.04.056"xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Shirouzu M."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Handa N."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Arakawa A."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/author | "Tezuka Y."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/pages | "334-338"xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/title | "Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97)."xsd:string |
http://purl.uniprot.org/citations/23624197 | http://purl.uniprot.org/core/volume | "435"xsd:string |
http://purl.uniprot.org/citations/23624197 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23624197 |
http://purl.uniprot.org/citations/23624197 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23624197 |
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http://purl.uniprot.org/uniprot/#_Q12959-mappedCitation-23624197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624197 |
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