| http://purl.uniprot.org/citations/23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23624311 | http://www.w3.org/2000/01/rdf-schema#comment | "The ciliary margin (CM) develops in the peripheral retina and gives rise to the iris and the ciliary body. The Wnt/β-catenin signalling pathway has been implicated in ciliary margin development. Here, we tested the hypothesis that in the developing mouse retina Foxg1 is responsible for suppressing the Wnt/β-catenin pathway and restricting CM development. We showed that there is excess CM tissue in Foxg1(-/-) null embryos and this expansion is more pronounced in the nasal retina where Foxg1 normally shows its highest expression levels. Results on expression of a reporter allele for Wnt/β-catenin signalling and of Lef1, a target of Wnt/β-catenin signalling, displayed significant upregulation of this pathway in Foxg1(-/-) nulls at embryonic days 12.5 and 14.5. Interestingly, this upregulation was observed specifically in the nasal retina, where normally very few Wnt-responsive cells are observed. These results indicate a suppressive role of Foxg1 on this signalling pathway. Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2013.04.017"xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/author | "Smith R."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/author | "Pratt T."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/author | "Price D.J."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/author | "Fotaki V."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/pages | "299-313"xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/title | "Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/beta-catenin signalling in the developing nasal retina of the mouse."xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://purl.uniprot.org/core/volume | "380"xsd:string |
| http://purl.uniprot.org/citations/23624311 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23624311 |
| http://purl.uniprot.org/citations/23624311 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23624311 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTS5-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV79-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUZ8-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A0A5H1ZRM6-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-23624311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624311 |