| http://purl.uniprot.org/citations/23624644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23624644 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the relevance of signaling mechanisms regulated by the Ras-homologous GTPase Rac1 for survival of acute myeloid leukemia (AML) cells harbouring the MLL-AF9 oncogene due to t(9;11)(p21;q23) translocation. Monocytic MLL-AF9 expressing cells (MM6, THP-1) were hypersensitive to both small-molecule inhibitors targeting Rac1 (EHT 1864, NSC 23766) (IC50EHT ~12.5 μM) and lipid lowering drugs (lovastatin, atorvastatin) (IC50Lova ~7.5 μM) as compared to acute myelocytic leukemia (NOMO-1, HL60) and T cell leukemia (Jurkat) cells (IC50EHT >30 μM; IC50Lova >25 μM). Hypersensitivity of monocytic cells following Rac1 inhibition resulted from caspase-driven apoptosis as shown by profound activation of caspase-8,-9,-7,-3 and substantial (~90 %) decrease in protein expression of pro-survival factors (survivin, XIAP, p-Akt). Apoptotic death was preceded by S139-posphorylation of histone H2AX (γH2AX), a prototypical surrogate marker of DNA double-strand breaks (DSBs). Taken together, abrogation of Rac1 signaling causes DSBs in acute monocytic leukemia cells harbouring the MLL-AF9 oncogene, which, together with downregulation of survivin, XIAP and p-Akt, results in massive induction of caspase-driven apoptotic death. Apparently, Rac1 signaling is required for maintaining genetic stability and maintaining survival in specific subtypes of AML. Hence, targeting of Rac1 is considered a promising novel strategy to induce lethality in MLL-AF9 expressing AML."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-013-0842-6"xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Fritz G."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Kaina B."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Huelsenbeck J."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Hinterleitner C."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Henninger C."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Schorr A."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/author | "Wartlick F."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/pages | "963-979"xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/title | "Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death."xsd:string |
| http://purl.uniprot.org/citations/23624644 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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